CA-4948 is a potent IRAK4/FLT3 inhibtor with anti-tumor activity.
体外研究
CA-4948 is over 500-fold more selective for IRAK-4 compared to IRAK-1. CA-4948 reduces TNF-α, IL-1β, IL-6 and IL-8 release from TLR-Stimulated THP-1 Cells with an IC50 <250 nM. CA-4948 also has antiproliferative activity due to inhibition of receptor-type tyrosine-protein kinase FLT3.
体内研究
CA-4948 shows anti-tumor activity in animal models including tumors containing MyD88 gene mutations. CA-4948 shows antileukemic activity in mouse models of FLT3 wild-type and FLT3 mutated acute myeloid leukemia (AML).
分子式
C24H25N7O5
分子量
491.50
CAS号
1801344-14-8
运输条件
Room temperature in continental US; may vary elsewhere.