AZ191 is a potent inhibitor that selectively inhibits DYRK1B with IC50 of 17 nM.
体外研究
AZ191 (0.01-60μM; 5 days) inhibits SW872 and SW982 cell lines in dose-dependent manner with IC50s of 3.183 μM and 1.279 μM, respectively.
AZ191 (1-5 μM; 48 hours) down-regulates three anti-apoptotic proteins (Bcl-2, p21, and survivin) at higher concentrations.
Cell Proliferation Assay
Cell Line:
SW872, SW982 liposarcoma cells
Concentration:
0.01, 0.03, 0.1, 0.3, 0.6, 1, 3, 6, 10, 20, 60 μM
Incubation Time:
5 days
Result:
Dose-dependent growth inhibition with IC50s of 3.183 μM and 1.279 μM for SW872 and SW982 cell lines, respectively.
Western Blot Analysis
Cell Line:
SW872, SW982 liposarcoma cells
Concentration:
1, 2, 3, 4, 5 μM
Incubation Time:
48 hours
Result:
Down-regulated three anti-apoptotic proteins (Bcl-2, p21, and survivin) at higher concentrations.
分子式
C24H27N7O
分子量
429.52
CAS号
1594092-37-1
运输条件
Room temperature in continental US; may vary elsewhere.