STL127705 (Compound L) 是一种 Ku 70/80 异二聚体蛋白 (Ku 70/80 heterodimer protein) 抑制剂，抑制 Ku70/80-DNA 相互作用，IC50 值为 3.5 μM。STL127705 可抑制 Ku 依赖性 DNA-PKCS 激酶的活化，IC50 值为 2.5 μM。
| 生物活性 |
STL127705 (Compound L) is a Ku 70/80 heterodimer protein inhibitor, inhibits Ku70/80-DNA interaction, with an IC50 of 3.5 μM. STL127705 also inhibits Ku-dependent activation of DNA-PKCS kinase (IC50, 2.5 μM). |
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| 分子式 |
C22H20FN5O4
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| 分子量 |
437.42
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| CAS号 |
1326852-06-5
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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| 溶解性数据 |
In Vitro:
H2O : < 0.1 mg/mL (insoluble) DMSO : < 1 mg/mL (insoluble or slightly soluble) *STL127705 is usually formulated as a suspension. |
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| 科研文献 |
纯度： ≥98%
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