GNE-6776 is a selective and orally bioavailable USP7 inhibitor.
IC50&Target
USP7
体外研究
GNE-6776 significantly inhibits USP7 at 15 µM. GNE-6776 is a highly selective USP7 inhibitor against both recombinant and endogenous cellular deubiquitinases.
体内研究
GNE-6776 (100 or 200 mg/kg; oral gavage on a once or twice daily schedule; for 10 days) inhibits EOL-1 xenograft growth in mice.
Animal Model:
Immunodeficient C.B-17 SCID mice (aged 12-16 weeks) with EOL1 AML xenograft
Dosage:
100 or 200 mg/kg
Administration:
Oral gavage on a once or twice daily schedule; for 10 days
Result:
Significant EOL-1 xenograft growth inhibition.
分子式
C20H20N4O2
分子量
348.40
CAS号
2009273-71-4
运输条件
Room temperature in continental US; may vary elsewhere.