IM-12 (129669-05-1) is a potent and selective inhibitor of glycogen synthase kinase 3ß (GSK-3ß) IC50=53 nM which induces neuronal differentiation. Activates the Wnt-ß-catenin signaling pathway and attenuates tissue plasminogen activator-induced hemorrhagic transformation after acute ischemic stroke in animal models. Promoted hair follicle growth in vitro and antagonized the inhibition of hair follicles by dihydrotestosterone. Down-regulates Sox9 expression in limbal epithelial stem/progenitor cells leading to increased differentiation.