2′,3′-cGAMP (CAS 1441190-66-4) is an endogenous STING (stimulator of interferon genes) agonist. Produced from ATP and GTP via the action of cGMP-AMP synthase (cGAS) which acts as a cytosolic DNA sensor. Induces autophagy which is a mechanism for clearance of DNA and viruses in the cytosol. DNA damage stimulates 2’,3’-cGAMP which stimulates an inflammatory response.