680C91
(Synonyms:6-氟-3-[(1E)-2-(3-吡啶基)乙烯基]-1H-吲哚)
目录号 : KF1026
CAS No. : 163239-22-3
纯度 : 98%
680C91 (163239-22-3) is a potent and selective inhibitor of tryptophan 2,3-dioxygenase (TDO) Ki=42 nM). Displays no activity against indoleamine 2,3-dioxygenase, MAO-A and B and does not effect serotonin uptake. Elevates CSF tryptophan by up to 260% and CSF serotonin by 170% of basal. TDO inhibition by 680C91 in glioma cells blocked the release of kynurenine , an endogenous tumor promoting AHR ligand.
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| 分子式 |
C15H11FN2
|
| 分子量 |
238.27
|
| CAS号 |
163239-22-3
|
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