AI-1
目录号 : KF1031
CAS No. : 75483-04-4
纯度 : 98%
AI-1 (75483-04-4) is a novel antioxidant response element (ARE) activator which activates Nrf2 by covalently modifying Keap1 (Kelch-like ECH-associated protein 1) a negative regulator of Nrf2. Modification of Cys151 of Keap1 by AI-1 disrupts the ability of Keap1 to serve as an adaptor for Cul3-Keap1 ubiquitin ligase complex, thereby stabilizing and inducing transcriptional activation of Nrf2. AI-1 is a useful pharmacological tool for probing the involvement of Nrf2 in cellular physiology. Cell permeable.
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| 分子式 |
C13H12ClNO3
|
| 分子量 |
265.7
|
| CAS号 |
75483-04-4
|
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