AA43279
目录号 : KF1094
CAS No. : 354812-16-1
纯度 : 97%
AA43279 (354812-16-1) is a selective Nav1.1 activator. In HEK-293 cells expressing human Nav1.1 channels AA43279 increased the Nav1.1-mediated current in a concentration dependent manner (EC50=9.5 μM). In rat hippocampal brain slices it increased the firing activity of parvalbumin-expressing, fast-spiking GABAergic interneurons and increased the spontaneous inhibitory post-synaptic currents recorded from pyramidal neurons. It displayed anticonvulsant activity in vivo. Important tool compound for exploring the physiology of Nav1.1 channels.
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| 分子式 |
C12H12N2O2S
|
| 分子量 |
248.3
|
| CAS号 |
354812-16-1
|
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