AI-3
(Synonyms:AI-3)
目录号 : KF1035
CAS No. : 882288-28-0
纯度 : 98%
AI-3 (882288-28-0) is an activator of antioxidant response element (ARE) which induces cytoprotective genes in human cells. It alkylates Keap1 at Cys151 and is reactive toward additional cysteines at higher concentrations. Disrupts Nrf2/Keap1 and Keap1/Cul3 interactions and stabilizes Nrf2. AI-3 activates ARE in an Nrf2 and PI 3-kinase dependent manner. Cell permeable and active in vivo.
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| 分子式 |
C11H13ClO3S2
|
| 分子量 |
292.81
|
| CAS号 |
882288-28-0
|
| 中文名称 |
AI-3
|
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