GSK-J5 (hydrochloride) - CAS:1797983-32-4

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GSK-J5 (hydrochloride)

目录号 : KCM12064 CAS No. : 1797983-32-4 纯度 : ≥95%

Data Sheet 产品使用指南

The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer. GSK-J4 is a cell-permeable prodrug which is modified by intracellular esterases to give GSK-J1 , an inhibitor of JMJD3. GSK-J5 is a pyridine regio-isomer of GSK-J4. Like GSK-J4, this isomer is cell-permeable and hydrolyzed to a free base. However, the free base is a weak inhibitor of JMJD3 (IC > 100 μM), making it an ideal inactive control molecule for elucidating the functional role of JMJD3 inhibition.

规格	价格	是否有货	数量
1mg		In-stock
5mg		In-stock
10mg		In-stock
50mg		In-stock

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分子式	C₂₄H₂₇N₅O₂^.HCl
分子量	417.54
CAS号	1797983-32-4
中文名称	N-[2-(3-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine,ethylester,monohydrochoride
储存方式	-20°C