13Z,16Z-Docosadienoic acid is a natural ω-6 polyunsaturated fatty acid (PUFA). It is an agonist of free fatty acid receptor 4 (FFAR4, also known as GPR120) and strongly inhibits the secretion of ghrelin by isolated mouse gastric cells. This 20:2 PUFA has been identified in mammals, fish, plants, and anaerobic fungi.
13Z,16Z-Docosadienoic Acid is a GPR120 agonist with bactericidal activity. 13Z,16Z-Docosadienoic acid serves as a potential biomarker for canine mammary tumors. 13Z,16Z-Docosadienoic acid is used in the research of bacterial infections, Lyme disease, Graves' disease and mammary tumors.
IC50&Target
Human Endogenous Metabolite
体外研究
13Z,16Z-docosadienoic acid (24-72 h) exhibits bacteriostatic activity against Borrelia burgdorferi s.s. (B31 strain) and Borrelia garinii (CIP103362 strain) during both the logarithmic and stationary growth phases, with an MIC of 0.025 mg/mL; it also demonstrates bactericidal activity, with an MBC90 of 0.5 mg/mL.
体内研究
13Z,16Z-Docosadienoic acid is significantly upregulated in canine mammary tumor tissues and can serve as a potential biomarker for this disease.
分子式
C22H40O2
分子量
336.55
CAS号
17735-98-7
中文名称
二十二碳二烯酸;顺13,16-二十二碳二烯酸;二十二碳二烯酸(顺-13,16)
运输条件
Room temperature in continental US; may vary elsewhere.