LSN 3213128 is a selective, nonclassical, orally bioavailable antifolate with potent and specific inhibitory activity for aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT), with IC50 of 16 nM for AICARFT enzyme inhibiton and 19 nM in cells. Anti-tumor activity.
IC50&Target
IC50: 16 nM (AICARFT), 19 nM (AICARFT in cells)
分子式
C17H16FN3O4S2
分子量
409.46
CAS号
1941211-99-9
运输条件
Room temperature in continental US; may vary elsewhere.