CD532 hydrochloride
目录号 : KM3424 纯度 : 98%

CD532 hydrochloride 是一种有效的 Aurora A 激酶抑制剂,IC50 值为 45 nM。CD532 hydrochloride 具有阻断 Aurora A 激酶活性和驱动 MYCN 降解的双重作用。CD532 hydrochloride 还可以直接与 AURKA 相互作用并诱导整体构象转变。CD532 hydrochloride 可用于癌症的研究。

规格 价格 是否有货 数量
5mg
In-stock
10mg
In-stock
25mg
In-stock
50mg 询价 In-stock
100mg 询价 In-stock

Other Forms of Rapamycin:

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生物活性

CD532 hydrochloride is a potent Aurora A kinase inhibitor with an IC50 of 45 nM. CD532 hydrochloride has the dual effect of blocking Aurora A kinase activity and driving degradation of MYCN. CD532 hydrochloride also can directly interact with AURKA and induces a global conformational shift. CD532 hydrochloride can be used for the research of cancer.

体内研究
Animal Model: Homozygous nu/nu mice with SHH-subtype MYCN-expressing medulloblastoma
Dosage: 25 mg/kg
Administration: I.p. twice weekly for 3 weeks
Result: Decreased the level of MYCN protein and tumor volume and increases survival.
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
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