GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.
1) GNF-6231 shows IC50s of greater than 10 μM on all CYP isoforms tested
2) GNF-6231 have favorable potency and a PK profile across preclinical species upon oral administration.
3) The reference for orally in MMTV-Wnt1 tumor bearing mice is dosed at 3 mg/kg.
4) GNF-6231 showed very robust dose-related antitumor efficacy.
分子式
C24H25FN6O2
分子量
448.49
CAS号
1243245-18-2
运输条件
Room temperature in continental US; may vary elsewhere.