SANT-1, a potent Smo antagonist, inhibits Hedgehog signaling. SANT-1 shows IC50s of 20 nM and 30 nM in Shh-LIGHT2 and SmoA1-LIGHT2 assay, respectively.
体外研究
SANT-1 is a potent Smo antagonist, binds directly to Smo, and inhibits Hedgehog signaling, with IC50s of 20 nM and 30 nM in Shh-LIGHT2 and SmoA1-LIGHT2 cells, respectively.
SANT-1 (1 μM, for 24 or 48 hours) decreases the proliferation of medulloblastoma cells.
Cell Viability Assay
Cell Line:
Medulloblastoma cells
Concentration:
1 μM
Incubation Time:
24 hours or 48 hours
Result:
Inhibited cellular proliferation in primary tumorspheres.
分子式
C23H27N5
分子量
373.49
CAS号
304909-07-7
运输条件
Room temperature in continental US; may vary elsewhere.