CH7057288 is a potent and selective TRK inhibitor.
体外研究
CH7057288 induces regression of intracranial tumors and greatly improves event-free survival in an intracranial implantation model mimicking brain metastasis. CH7057288 can be a promising therapeutic agent for TRK fusion-positive cancer. TRK receptor tyrosine kinases are expressed as fusion proteins encoded by various fusion genes across a wide variety of cancer types, including lung and colorectal cancer.
分子量
569.67
CAS号
2095616-82-1
运输条件
Room temperature in continental US; may vary elsewhere.