KDU731 - CAS:1610610-48-4

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KDU731

目录号 : KM2529 CAS No. : 1610610-48-4 纯度 : 98%

Data Sheet 产品使用指南

KDU731，具有口服活性的 C. parvum PI4K 抑制剂，阻断体内外隐孢子虫感染，IC₅₀ 值为 25 nM。KDU731 是研究隐孢子虫引起的腹泻的有望候选药物，具有广泛的安全性。

规格	价格	是否有货
1mg		In-stock
5mg		In-stock
10mg		In-stock
50mg	询价	In-stock
100mg	询价	In-stock

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Antitrypanosomal agent 2 In-stock
1,2,3,4-Tetrahydronorharman-1-one In-stock

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生物活性

KDU731, an orally active C. parvum PI4K inhibitor with an IC₅₀ value of 25 nM, blocks Cryptosporidium infection in vitro and in vivo. KDU731 is a promising drug candidate for the treatment of diarrhea caused by Cryptosporidium and meets a broad range of safety.

体内研究

KDU731 (orally administration; 7 or 10mg/kg; 16 days) has potent activity against Cryptosporidium in immunocompromised IFN-γ KO mice and dramatically reduces oocyst shedding.
KDU731 (orally administration; 5 mg/kg; every 12 hours for 7 days) is tolerated in all calves, and treated calves shed significantly fewer oocysts than vehicle treated calves in their stool.

Animal Model:	6-8 week old C57BL/6 IFN-γ-knockout mice with 10,000 oocysts
Dosage:	7 or 10 mg/kg
Administration:	Orally administration; 7 or 10 mg/kg; 16 days
Result:	Resulted in significant reduction of oocyst shedding.

Animal Model:	Neonatal calves with 5 x 10 oocysts
Dosage:	5 mg/kg
Administration:	Orally administration; 5 mg/kg; every 12 hours for 7 days
Result:	Resulted in significant reduction of oocyst shedding in treated calves in their stool.

分子式

C₂₂H₁₆N₆O₂

分子量

396.40

CAS号

1610610-48-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 83.33 mg/mL (210.22 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.5227 mL	12.6135 mL	25.2270 mL
5 mM	0.5045 mL	2.5227 mL	5.0454 mL
10 mM	0.2523 mL	1.2614 mL	2.5227 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： 98%

Data Sheet

产品使用指南

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

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Other Forms of Rapamycin:

KKL 顾客使用本产品发表的 0 篇科研文献

The molarity calculator equation

The dilution calculator equation