Gadolinium chloride is a specific calcium-sensing receptor (CaSR) agonist. Gadolinium chloride can be used for the research of cardiovascular disease.
IC50&Target
CaSR
体外研究
Gadolinium chloride (30 μM; 15 minutes; H9c2 cells) results in increased Bax expression and caspase-3 activation, and decreased Bcl-2 expression in CsA-induced cells.
In vitro, GdCl3, a CaSR agonist, has been shown to promote the apoptosis of myocardial cells, which increases ERK1/2 phosphorylation and activates caspase-3.
Western Blot Analysis
Cell Line:
H9c2 cells
Concentration:
30 μM
Incubation Time:
15 minutes
Result:
Resulted in increased Bax expression and caspase-3 activation, and decreased Bcl-2 expression in CsA-induced cells.
分子式
Cl3Gd
分子量
263.61
CAS号
10138-52-0
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder
-20°C
3 years
4°C
2 years
In solvent
-80°C
6 months
-20°C
1 month
溶解性数据
In Vitro:
1M HCl : 100 mg/mL (379.35 mM; ultrasonic and adjust pH to 1 with HCl)
DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble)
H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)