GNF351 is a full aryl hydrocarbon receptor (AHR) antagonist. GNF351 competes with a photoaffinity AHR ligand for binding to the AHR with an IC50 of 62 nM. GNF351 is minimal toxicity in mouse or human keratinocytes.
IC50&Target
IC50: 62 nM (aryl hydrocarbon receptor)
体外研究
GNF351 (500 nM, 48 hours) significantly reduces the percentage of Ki67-positive cells and cell number after treating proliferating monolayer cultures of human keratinocytes.
Cell Proliferation Assay
Cell Line:
Human primary keratinocytes
Concentration:
500 nM
Incubation Time:
48 hours
Result:
Showed a significant reduction in the percentage of Ki67-positive cells and cell number after treating proliferating monolayer cultures of human keratinocytes for 48 hours.
分子式
C24H25N7
分子量
411.50
CAS号
1227634-69-6
运输条件
Room temperature in continental US; may vary elsewhere.