BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 μM, respectively).
IC50 value: 289 nM (HDAC3), 2 μM (HDAC1), 2.2 μM (HDAC2), >20 μM (HDAC6)
Target: HDAC
At concentrations up to 50 mg/kg, BG45 alone or in combination with Bortezomib has been shown to dose-dependently inhibit tumor growth in a mouse model of multiple myeloma.1
IC50&Target
HDAC3
0.289 μM (IC50)
HDAC1
2.0 μM (IC50)
HDAC2
2.2 μM (IC50)
分子式
C11H10N4O
分子量
214.22
CAS号
926259-99-6
运输条件
Room temperature in continental US; may vary elsewhere.