(-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca-permeable nonselective cation channel, to increase [Ca]i. Antitumor activity.
IC50&Target
Human Endogenous Metabolite
体外研究
(-)-Menthol (Menthol ) per se does not exhibit antiproliferative activity, but it is able to enhance 1α,25(OH)2D3-mediated growth inhibition in LNCaP cells. At high (-)-Menthol concentrations above 1.6 mM, the cells begin to detach from the culture dish.
(-)-Menthol (0.8 mM) can increase [Ca]i via transmembrane influx or store release pathways. Peak increase in [Ca]i was 102.3±39 nM (n=3) in (-)-Menthol alone and 124.5±51 nM (n=3) in combination of 1α,25(OH)2D3 with (-)-Menthol, respectively.
Combination of 1α,25(OH)2D3 with (-)-Menthol (0.8 mM) cooperatively modulates bcl-2 and p21 expression.
分子式
C10H20O
分子量
156.27
CAS号
2216-51-5
中文名称
(-)-薄荷醇
运输条件
Room temperature in continental US; may vary elsewhere.