Pranlukast-d5 是 Pranlukast 的氘代物。Pranlukast 是一种高效的竞争性的选择性 leukotriene 拮抗剂。Pranlukast 抑制 [3H]LTE4，[3H]LTD4 和 [3H]LTC4 与肺膜结合，Ki 分别为 0.63，0.99 和 5640 nM。
| 生物活性 |
Pranlukast-d5 (ONO-1078-d5) is the deuterium labeled Pranlukast. Pranlukast is a highly potent, selective and competitive antagonist of peptide leukotrienes. Pranlukast inhibits [H]LTE4, [H]LTD4, and [H]LTC4 bindings to lung membranes with Kis of 0.63, 0.99, and 5640 nM, respectively. |
|---|---|
| 体外研究 |
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. |
| 分子量 |
486.53
|
| CAS号 |
1216719-50-4
|
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
客服小K 
客服小K
Data Sheet
