PF-4618433 is a potent and selective PYK2 inhibitor, with an IC50 of 637 nM. PF-4618433 may be suitable for the research of osteoporosis, craniofacial and appendicular skeletal defects and for targeted bone regeneration.
IC50&Target
IC50: 637 nM (PYK2)
体外研究
PF-4618433 (0.1-1.0 μM; 7 days) promotes osteogenesis of hMSC cultures. PF-4618433 increases in both alkaline phosphatase (ALP) activity and mineralization in a dependent manner.
PF-4618433 (0.1-0.3 μM; 24 hours) enhances osteoblast proliferation.
PF-4618433 (0.0125-0.3 μM; 14 or 21 days) enhances calcium deposition at the concentrations of 0.1 and 0.3 μM.
Cell Proliferation Assay
Cell Line:
Murine bone marrow-derived mesenchymal stem cells (BMSC)
Concentration:
0.1, 0.3 μM
Incubation Time:
24 hours
Result:
Increased cell proliferation activity significantly when compared to the untreated or control group.
分子式
C24H27N7O2
分子量
445.52
CAS号
1166393-85-6
运输条件
Room temperature in continental US; may vary elsewhere.