BMS-5 (LIMKi 3) is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively.
IC50&Target
LIMK1
7 nM (IC50)
LIMK2
8 nM (IC50)
体外研究
BMS-5 (LIMKi 3) inhibits cofilin-Ser3 phosphorylation in a dose-dependent manner in Nf2 mouse Schwann cells (MSCs) with an IC50 of ~2 µM. BMS-5 (LIMKi 3) reduces Nf2 MSC viability in a dose-dependent manner with an IC50 of 3.9 µM, but does not significantly reduce the viability of control Nf2 MSCs at equivalent BMS-5 concentrations. At 10 µM BMS-5, Nf2 MSC viability is 40% compared to 83% for controls.
体内研究
BMS-5 (LIMKi 3) (20 or 200 μM/side) is bilaterally infused into the hippocampus of rats immediately after contextual fear conditioning training. Rats are tested for memory consolidation 48 h after fear conditioning. Post hoc analysis shows that the group treated with 200 μM BMS-5 express lower freezing levels compared to the 20 μM and vehicle groups (P<0.01).
分子式
C17H14Cl2F2N4Os
分子量
431.29
CAS号
1338247-35-0
运输条件
Room temperature in continental US; may vary elsewhere.