GNE 220 (hydrochloride) is a potent and selective inhibitor of MAP4K4, with an IC50 of 7 nM.
体外研究
GNE-220 also inhibits a few other kinases with IC50s of 9 nM, 476 nM and 1.1 μM for MINK (MAP4K6), DMPK and KHS1 (MAP4K5), respectively. GNE-220 alters human umbilical vein endothelial cells (HUVEC) sprout morphology. GNE-220 also reduces pERM retraction fibres in a dose-dependent manner. GNE-220 also dose-dependently increased the number of active-INTβ1 long focal adhesions (FAs).
分子式
C25H27ClN8
分子量
474.99
CAS号
2448286-21-1
运输条件
Room temperature in continental US; may vary elsewhere.