DPBQ 以多倍体特异性方式激活 p53 并触发凋亡 (apoptosis)，但不抑制拓扑异构酶或结合 DNA。DPBQ 引起 p53 的表达和磷酸化，这种作用是四倍体细胞特有的。
| 生物活性 |
DPBQ activates p53 and triggers apoptosis in a polyploid-specific manner, but does not inhibit topoisomerase or bind DNA. DPBQ elicits expression and phosphorylation of p53 and this effect is specific to tetraploid cells. |
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| 体外研究 |
DPBQ elicits apoptosis and cell death and is selective for effects in 4N cells. DPBQ elicits expression and phosphorylation of p53 and this effect is specific to tetraploid cells. Knockdown of TP53 restores proliferation of tetraploid cells in the presence of DPBQ. |
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| 分子式 |
C24H14N2O2
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| 分子量 |
362.38
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| CAS号 |
7029-89-2
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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| 科研文献 |
纯度： ≥98%
客服小K 
客服小K
Data Sheet
