Balsalazide could suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.
IC50&Target
IL-6
STAT3
体内研究
At the endpoint, the protein production of MIP-1β, MCP-1, IL-6, and IL-10 in the colon tissues decrease in concordance with the plasma concentrations of the cytokines. The drug-treated groups reveal lower expression of p-STAT3 compared to the CAC group. In addition, BCL2 decreases and BAX increases markedly in the BSZ+VSL#3 group. Balsalazide is a new 5-aminosalicylic acid (5-ASA) containing prodrug.
分子式
C17H15N3O6
分子量
357.32
CAS号
80573-04-2
中文名称
巴柳氮;巴沙拉嗪
运输条件
Room temperature in continental US; may vary elsewhere.