Apigenin-7-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively.
IC50&Target
MMP-3
12.87 μM (IC50)
MMP-8
22.39 μM (IC50)
MMP-9
17.52 μM (IC50)
MMP13
0.27 μM (IC50)
体外研究
Apigenin-7-Oglucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively . Scutellarin A also inhibits the migrated capacity of ACHN and 786-O cells in a dose-dependent manner. It is also revealed that after treatment with Scutellarin A (30, 60, and 90 μM) for 24 h, the apoptosis rates in ACHN and 786-O cells are remarkably enhanced dose-dependently when compared to the control groups.
分子式
C21H18O11
分子量
446.36
CAS号
29741-09-1
运输条件
Room temperature in continental US; may vary elsewhere.