Clopidogrel hydrogen sulfate - CAS:120202-66-6

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Clopidogrel hydrogen sulfate (Synonyms:硫酸氢氯吡格雷; (S)-(+)-Clopidogrel bisulfate; (S)-(+)-Clopidogrel hydrogen sulfate)

目录号 : KM16258 CAS No. : 120202-66-6 纯度 : 98%

Data Sheet SDS 产品使用指南

Clopidogrel hydrogen sulfate 是一种抗血小板药物，可防止血栓形成。Clopidogrel hydrogen sulfate 抑制 CYP2B6和 CYP2C19， IC,sub>50 分别为 18.2 nM 和 524 nM。 Clopidogrel hydrogen sulfate 是一种有效的抗血栓剂，可抑制 ADP 诱导的血小板聚集。Clopidogrel hydrogen sulfate 也是一种具有口服活性 P2Y(12) 抑制剂。

规格	价格	是否有货
100mg		In-stock
500mg		In-stock
1g	询价	In-stock
5g	询价	In-stock

加入购物车大包装询价

Other Forms of Rapamycin:

Adenosine 3'-phosphate 5'-phosphosulfate In-stock
Prasugrel-d4 In-stock
1-[(5-methylisoxazol-3-yl)methyl]piperazine In-stock
Ticagrelor metabolite M5 In-stock
(±) Clopidogrel hydrogen sulfate In-stock

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生物活性

Clopidogrel hydrogen sulfate is an antiplatelet agent to prevent blood clots. Clopidogrel hydrogen sulfate inhibits CYP2B6 and CYP2C19 with IC₅₀s of 18.2 nM and 524 nM, respectively. Clopidogrel hydrogen sulfate is a potent antithrombotic agent that inhibits ADP-induced platelet aggregation．Clopidogrel hydrogen sulfate also is an orally active P2Y(12) inhibitor.

IC₅₀&Target

CYP2B6

18.2 nM (IC₅₀)

CYP2C19

524 nM (IC₅₀)

体外研究

Clopidogrel (1.5 mM;12 and 24 hours) up-regulates the expression of TRIB3 and CHOP in a concentration- and time-dependent manner, as measured by real-time PCR and Western blot analysis.
Clopidogrel (1.5 mM; 24 hours) significantly induces human gastric epithelial cell (GES-1) apoptosis.

Western Blot Analysis

Cell Line:	GES-1 cells
Concentration:	1.5 mM
Incubation Time:	12 and 24 hours
Result:	The mRNA expression levels of both CHOP and TRIB3 were up-regulated in a concentration- and time-dependent manner. The protein expression levels of both CHOP and TRIB3 were up-regulated in a concentration- and time-dependent manner.

Apoptosis Analysis

Cell Line:	Gastric epithelial cell (GES-1) cells
Concentration:	1.5 mM
Incubation Time:	24 hours
Result:	Induced apoptosis of gastric epithelial cells．

体内研究

Clopidogrel (5 mg/kg) significantly inhibits thrombus formation compared with vehicle. Acetylsalicylic acid (0.15 mg/kg) can add to the antithrombotic effect of Clopidogrel in mice; Acetylsalicylic acid (0.6 mg/kg) blunts the antithrombotic effect of Clopidogrel.

Animal Model:	Age-matched C57BL/6J male mice weighing at least 25 g were used at 8 to 12 weeks of age
Dosage:	5 mg/kg
Administration:	Gavage treatment
Result:	Clopidogrel significantly inhibited thrombus formation compared with vehicle. When Clopidogrel was given in combination with 0.6 mg/kg ASA, thrombi were significantly larger than those measured with Clopidogrel alone. In contrast, when Clopidogrel was given in combination with 0.15 mg/kg ASA , thrombi were significantly smaller than those in mice treated with Clopidogrel and 0.6 mg/kg ASA, and smaller than those in mice given Clopidogrel alone.

分子式

C₁₆H₁₈ClNO₆S₂

分子量

419.90

CAS号

120202-66-6

中文名称

硫酸氢氯吡格雷

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 200 mg/mL (476.30 mM; Need ultrasonic)

H₂O : 16.67 mg/mL (39.70 mM; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3815 mL	11.9076 mL	23.8152 mL
5 mM	0.4763 mL	2.3815 mL	4.7630 mL
10 mM	0.2382 mL	1.1908 mL	2.3815 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO → 90% (20% SBE-β-CD in saline)

Solubility: ≥ 5 mg/mL (11.91 mM); Clear solution

此⽅案可获得 ≥ 5 mg/mL (11.91 mM，饱和度未知) 的澄清溶液。

以 1 mL ⼯作液为例，取 100 μL 50.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD ⽣理盐⽔⽔溶液中，混合均匀。
2.

请依序添加每种溶剂： 10% DMSO → 90% corn oil

Solubility: ≥ 5 mg/mL (11.91 mM); Clear solution

此⽅案可获得 ≥ 5 mg/mL (11.91 mM，饱和度未知) 的澄清溶液，此⽅案不适⽤于实验周期在半个⽉以上的实验。

以 1 mL ⼯作液为例，取 100 μL 50.0 mg/mL 的澄清 DMSO 储备液加到 900 μL ⽟⽶油中，混合均匀。

临床试验

科研文献

纯度： 98%

Data Sheet

SDS

产品使用指南

暂无相关参考文献

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

重置计算

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

重置计算

动物实验计算换算器

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系客服为您提供正确的澄清溶液配方）

% DMSO

% Tween 80

% ddH₂O

% DMSO

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系客服）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

配置后的溶液总体积：

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

Other Forms of Rapamycin:

KKL 顾客使用本产品发表的 8 篇科研文献

The molarity calculator equation

The dilution calculator equation

动物实验计算换算器