CTX1 是一种 p53 激活物，可以克服 HdmX 介导的 p53 抑制。CTX1 在小鼠急性髓系白血病 (AML) 模型中显示出强大的抗癌活性。
| 生物活性 |
CTX1 is a p53 activator that overcomes HdmX-mediated p53 repression. CTX1 exhibits potent anti-cancer activity in a mouse acute myeloid leukemia (AML) model system. |
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| 体外研究 |
CTX1 binds directly to HdmX to prevent p53-HdmX complex formation, resulting in the rapidly induction of p53 in a DNA damage-independent manner. |
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| 体内研究 |
CTX1 ( (30 mg/kg; i.p.; five days a week; for 3 weeks) significantly enhances the survival of mice in AML model system.
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| 分子式 |
C14H10N4
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| 分子量 |
234.26
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| CAS号 |
501935-96-2
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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| 科研文献 |
纯度： ≥96%
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