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(E)-[6]-Dehydroparadol, an oxidative metabolite of [6]-Shogaol , is a potent Nrf2 activator. (E)-[6]-Dehydroparadol can inhibit the growth and induce the apoptosis of human cancer cells.

(E)-[6]-Dehydroparadol (M15) (5-80 µM; 24 h) inhibits the growth of HCT-116 and H-1299 cells, with IC₅₀s of 43.02 and 41.59 µM, respectively.
(E)-[6]-Dehydroparadol (10-40 µM; 24 h) induces apoptosis in HCT-116 and H-1299 cells.

(E)-[6]-Dehydroparadol (compound 19) (5 µM; 24 h) enhances Tg[glutathione S-transferase pi 1 (gstp1):green fluorescent protein (GFP)] fluorescence signal in the Tg(gstp1:GFP) transgenic zebrafish embryos.

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