Oligomycin 是一种抗真菌抗生素，是 H+-ATP 合成酶的抑制剂。Oligomycin 断氧化磷酸化和电子传递链。Oligomycin 抑制缺氧性肿瘤细胞 HIF-1alpha 表达。
| 生物活性 |
Oligomycin, an antifungal antibiotic, is an inhibitor of H-ATP-synthase. Oligomycin blocks oxidative phosphorylation and the electron transport chain. Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells. |
|---|---|
| 体外研究 |
Oligomycin, inhibitor of the F0 part of H-ATP-synthase, suppresses the TNF-induced apoptosis. |
| 分子式 |
C45H74O11
|
| 分子量 |
791.07
|
| CAS号 |
1404-19-9
|
| 中文名称 |
寡霉素
|
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
-20°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) |
| 溶解性数据 |
In Vitro:
Ethanol : 30 mg/mL (Need ultrasonic and warming) DMSO : 20 mg/mL (Need ultrasonic and warming) |
| 科研文献 |
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