Nitidine chloride 是可从Zanthoxylum nitidum (Roxb) DC 中分离得到一种具有抗疟疾活性的化合物。Nitidine chloride 通过多个靶点通路，发挥抗癌活性，如诱导凋亡，抑制STAT3、DNA拓扑异构酶1和2A、ERK 和c-Src/FAK 相关信号通路。Nitidine chloride通过MAPK和NF-kB途径抑制Lps诱导的炎性细胞因子的产生。
| 生物活性 |
Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway. |
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| 分子式 |
C21H18ClNO4
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| 分子量 |
383.82
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| CAS号 |
13063-04-2
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| 中文名称 |
氯化两面针碱
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
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| 溶解性数据 |
In Vitro:
DMSO : 2 mg/mL (5.21 mM; Need ultrasonic) *Nitidine chloride is usually formulated as a suspension. 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
纯度： 98%
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