Artesunate is an inhibitor of both STAT-3 and exported protein 1 (EXP1).
IC50&Target
Stat-3
EXP1
体外研究
Artesunate is an inhibitor of both STAT-3 and exported protein 1 (EXP1). Artesunate treatment for 24 h causes a significant increase in the levels of reactive oxygen species (ROS) in a dose-dependent manner in both cell lines. Moreover, Western blotting shows that the levels ofγ-H2AX are significantly elevated when cancer cells are treated with Artesunate in the higher dose range for 24 h. Artesunate also shows a time-dependent effect on the level of RAD51 in A2780 and HO8910 cells. In two types of non-malignant cells, normal human fibroblasts and immortalized epithelial cells, FTE-187, the level of RAD51 is not altered by Artesunate. In A2780 cells, the level of RAD51 mRNA is indeed decreased by the addition of Artesunate, in a dose-dependent manner. Correspondingly, the promoter activity of RAD51 is significantly inhibited by Artesunate. In contrast, the RAD51 mRNA level in H8910 cells is not affected by Artesunate.
体内研究
Tumor growth is significantly reduced in the group receiving combined treatment of Artesunate and cisplatin (P<0.01). In comparison, Artesunate alone has no significant effect on the growth of tumor xenografts for both cell lines.
分子式
C19H28O8
分子量
384.42
CAS号
88495-63-0
中文名称
青蒿酯;青蒿琥酯;二氢青蒿素-12-α-丁二酸单酯;
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder
-20°C
3 years
4°C
2 years
In solvent
-80°C
6 months
-20°C
1 month
溶解性数据
In Vitro:
DMSO : 83.33 mg/mL (216.77 mM; Need ultrasonic)
7.5% sodium bicarbonate : 20 mg/mL (52.03 mM; Need ultrasonic)