Cearoin
目录号 : KM14807 CAS No. : 52811-37-7 纯度 : ≥98%

Cearoin 通过促进 ROS 产生和激活 ERK 来增强自噬 (autophagy) 和诱导细胞凋亡(apoptosis)。

规格 价格 是否有货 数量
1mg
In-stock
5mg 询价 In-stock
10mg 询价 In-stock

Other Forms of Rapamycin:

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生物活性

Cearoin increases autophagy and apoptosis through the production of ROS and the activation of ERK.

体外研究

Cearoin (10-80 μM) induces cell death in a dose-dependent manner.
Cearoin (10-80 μM) increases the phosporylation of ERK in SH-SY5Y cells.
Cearoin (5-80 μM) increases the conversion of LC3B-I to LC3B-II in SH-SY5Y cells. The expression of LC3B-II is a good marker for autophagosome formation in the autophagy process.

Cell Viability Assay

Cell Line: Human neuroblastoma SH-SY5Y cells
Concentration: 0, 1, 5, 10, 20, 40, or 80 μM
Incubation Time: 6 or 12 hours
Result: Significantly decreased cell viability from 10 μM in a dose-dependent manner. Treatment with 40 μM for 12 h induced about 50% loss in cell viability in SH-SY5Y cells.

Western Blot Analysis

Cell Line: Human neuroblastoma SH-SY5Y cells
Concentration: 0, 5, 10, 20, 40, or 80 μM
Incubation Time: 12 hours
Result: Increased ERK phosphorylation in a dose-dependent manner, whereas it did not alter JNK phosphorylation.
Induced the formation of LC3B-II in a dose dependent manner.
分子式
C14H12O4
分子量
244.24
CAS号
52811-37-7
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

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