BAY-598 is selective small molecule inhibitor of SMYD2 with an IC50 of 27 nM.
IC50&Target
IC50: 27 nM (SMYD2)
体外研究
BAY-598 treatment blocks in vitro methylation of MAPKAPK3 by SMYD2 but has no activity against the SMYD2-related KMT SMYD3. BAY-598 treatment reduces the growth of Kras;p53 mutant PDAC cells after 9 d in culture but has little impact on the growth of Kras;p53;Smyd2 mutant cells.
分子式
C22H20Cl2F2N6O3
分子量
525.34
CAS号
1906919-67-2
运输条件
Room temperature in continental US; may vary elsewhere.