CMK is a RSK2 kinase inhibitor which exhibits similar potency but less chemical stability compared with FMK.
体外研究
CMK inhibits the growth of Cdc5 (L158G) with IC50 of 36 nM, greater than 30 μM for wild type Cdc5. CMK exhibits a concentration-dependent first cell cycle mitotic arrest in the cdc5-as1 strain with an IC50 of 1.1 μM. CMK inhibition of Cdc5 (L158G) leads to a first cell cycle anaphase arrest and delay in anaphase spindle migration.
分子式
C18H19N4O2Cl
分子量
358.82
CAS号
821794-90-5
运输条件
Room temperature in continental US; may vary elsewhere.