AKT-IN-6 (Example 13) is a potent Akt inhibitor. AKT-IN-6 inhibits Akt1, Akt2 and Akt3 with IC50s < 500nM, respectively. (patent WO2013056015A1).
IC50&Target
Akt1
Akt2
Akt3
体外研究
Akt is a central node in cell signaling downstream of growth factors, cytokines, and other cellular stimuli. Aberrant loss or gain of Akt activation underlies the pathophysiological properties of a variety of complex diseases, including type-2 diabetes and cancer.
分子式
C22H20FN5O
分子量
389.43
CAS号
1430056-54-4
运输条件
Room temperature in continental US; may vary elsewhere.