Castanospermine inhibits all forms of α- and β-glucosidases, especially glucosidase l (required for glucoprotein processing by transfer of mannose and glucose from asparagine-linked lipids).
target:α- and β-glucosidases.
IC 50: 1.2 uM [2]
in vitro :Castanospermine, [(1 S,6S,7R,8R,8aR)-1 ,6,7,8-tetrahydroxyoctahydroindolizine]
is a potent and specific inhibitor of mammalian and plant α-and β-D-glucosidases in vitro [1]
in vivo: Experiments in vivo with castanospermine, an inhibitor of the glucosidases that convert protein N-linked high mannose carbohydrates to complex oligosaccharides, resulted in significant inhibition of tumor growth in nude mice.[3]
分子式
C8H15NO4
分子量
189.21
CAS号
79831-76-8
中文名称
亚胺糖栗树精胺
运输条件
Room temperature in continental US; may vary elsewhere.