Argatroban (monohydrate) (MD-805 (monohydrate)) is a direct, selective thrombin inhibitor.
IC50&Target
Thrombin.
体外研究
Argatroban (MD-805) may have a complementary effect for preventing thrombus formation without aggravating bleeding tendency because of its monotarget specificity to thrombin. Administration (0.5 to 2 micrograms/kg/min) of Argatroban (MD-805) is a safe anticoagulant for left heart bypass in repairs of traumatic aortic rupture associated with multiple organ injuries. Argatroban (MD-805), as compared with heparin, appears to enhance reperfusion with TPA in patients with AMI, particularly in those patients with delayed presentation. The incidences of major bleeding and adverse clinical outcome were lower in the patients receiving argatroban.
分子式
C23H38N6O6S
分子量
526.65
CAS号
141396-28-3
中文名称
阿加曲班一水合物
运输条件
Room temperature in continental US; may vary elsewhere.