MK-1064 is a selective orexin 2 receptor antagonist (2-SORA) for the research of insomnia.
target: 2-SORA [1]
In vivo: MK-1064 promotes sleep and increases both rapid eye movement (REM) and non-REM (NREM) sleep in rats at OX2R occupancies higher than the range observed for dual orexin receptor antagonists. MK-1064 increases NREM and REM sleep in dogs without inducing cataplexy. The reference for animal administration is 30 mg/kg. [2]
分子式
C24H20ClN5O3
分子量
461.90
CAS号
1207253-08-4
运输条件
Room temperature in continental US; may vary elsewhere.