DSPE-PEG-DBCO, MW 1000 是一种磷脂 PEG 聚合物，结合了疏水性磷脂 (DSPE)、分子量为 1000 Da 的亲水性聚乙二醇间隔基和反应性点击化学端基 (DBCO)。DSPE-PEG-DBCO 利用内源性白蛋白转运系统向淋巴结迁移，植入生物正交 DBCO 对接位点，并可通过点击化学介导叠氮功能化囊泡在淋巴结中的富集。DSPE-PEG-DBCO 可用于动脉粥样硬化的相关研究。
| 生物活性 |
DSPE-PEG-DBCO, MW 1000 is a phospholipid PEG polymer that combines a hydrophobic phospholipid (DSPE), a hydrophilic polyethylene glycol spacer with a molecular weight of 1000 Da, and a reactive click chemistry terminal group (DBCO). DSPE-PEG-DBCO migrates to lymph nodes via the endogenous albumin transport system, implants bioorthogonal DBCO docking sites, and enables the enrichment of azide-functionalized vesicles in lymph nodes mediated by click chemistry. DSPE-PEG-DBCO can be used in studies related to atherosclerosis. |
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| 体外研究 |
DSPE-PEG-DBCO, MW 1000 can be designed as the first dose (pre targeted anchor) of the two-component sonodynamic vaccine SenoVac: it efficiently migrates into lymph nodes by borrowing endogenous albumin and pre installs a bioorthogonal DBCO dock in the lymph nodes. When the second dose of azide SCAV arrives, it is specifically and long-acting locked in the lymph nodes through copper free click chemistry. |
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| 分子量 |
1000 (Average)
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
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| 溶解性数据 |
DMSO : 100 mg/mL (Need ultrasonic) |
纯度： 92%
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