InVivo Plus Anti-Mouse CTLA-4 Antibody (9D9) 是一种靶向小鼠 CTLA-4（CD152）的单克隆抗体，CTLA-4 是一种免疫检查点受体。该抗体可阻断 CTLA-4/B7 相互作用，并耗竭肿瘤内调节性T细胞（Tregs），从而增强小鼠模型中的抗肿瘤T细胞免疫反应。Anti-Mouse CTLA-4 Antibody（Clone 9D9）可用于免疫学和癌症相关研究。
| 生物活性 |
InVivo Plus Anti-Mouse CTLA-4 Antibody (9D9) is a mouse monoclonal antibody detecting CTLA-4 in ELISA, FCM, Functional assay, Research in vivo. Suitable for Mouse. |
|---|---|
| 分子量 |
~150 kDa
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| 储存方式 |
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 研究背景 |
Cytotoxic T-lymphocyte protein 4 (CD152/CTLA4) is a ~24 kDa protein. Inhibitory receptor acting as a major negative regulator of T-cell responses. Acts as a decoy receptor: the affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. CD152 is the therapeutic target of ipilimumab (Yervoy).
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| 种属反应性 |
Mouse
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| 宿主 |
Mouse
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| 同种型 |
Mouse IgG2b kappa
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| 表达系统 |
HEK293
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| Accession号 |
P09793
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| 应用 |
ELISA, FCM, Functional assay, Research in vivo
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| 性状 |
Liquid
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| 保存溶液 |
0.01M PBS pH 7.4.
|
| 基因 ID |
12477
|
| 纯度 |
>95% as determined by SDS-PAGE.
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| 内毒素含量 |
< 1 EU/mg as determined by LAL method.
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| 靶标 |
CD152, CTLA-4, CTLA4, Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4
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| 克隆号 |
9D9
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| 克隆类型 |
Monoclonal
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| 推荐同型对照抗体 |
IgG2a (LALA-PG) kappa
|
纯度： >95% as determined by SDS-PAGE
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