ATP magnesium (Synonyms:三磷酸腺苷镁盐;Adenosine 5'-triphosphate magnesium)
目录号 : KM32759 CAS No. : 1476-84-2 纯度 : 98%

ATP magnesium 是体内能量储存和代谢的重要物质,为代谢提供能量,同时在细胞中作为辅酶发挥作用。ATP magnesium 是免疫和炎症中重要的内源性信号分子。ATP magnesium 可激活 NLRP3 炎症小体,并诱导 IL-1β 和趋化因子的分泌。ATP magnesium 具有抗细菌感染作用,能保护小鼠免受细菌感染。

规格 价格 是否有货 数量
50mg
In-stock
100mg
In-stock

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生物活性

ATP magnesium is a central component of energy storage and metabolism in vivo. ATP magnesium provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP magnesium is an important endogenous signaling molecule in immunity and inflammation. ATP magnesium can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP magnesium has anti-bacterial infection effects and can protect mice against bacterial infection in mice.

体外研究

The co treatment of ATP (5 mM; 1 hour) magnesium and LPS has a synergistic effect on the activation of NLRP3 inflammasome in HGFs .
ATP magnesium (2 mM; 0.5-24 hours) induces BMDM secretion of IL-1 β, KC, and MIP-2 in a caspase-1 activation dependent manner.
ATP magnesium (2mM) promotes neutrophil chemotaxis.

体内研究

ATP (50 mg/kg, intraperitoneal injection, 1-24 hours before bacterial attack) magnesium can protect mice from bacterial infections such as Escherichia coli and Staphylococcus aureus .

 

Animal Model: Four-week-old Kunming mice infected with E. coli and S. aureus (18-22 g)
Dosage: 50 mg/kg
Administration:
Intraperitoneal injection, 1, 4, 24 h before bacterial (E. coli) challenge
Result: Reduced peritoneal bacterial counts.
Increased the levels of IL-1β, KC and MIP-2 in the peritoneal lavage fluid.
Recruited neutrophils to the peritoneum.
 
分子式
C10H16MgN5O13P3
分子量
529.49
CAS号
1476-84-2
中文名称
三磷酸腺苷镁盐
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
动物实验计算换算器
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系客服为您提供正确的澄清溶液配方)
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计算结果:

工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,

体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL ddH2O,混匀澄清。

配置后的溶液总体积:

1. 首先保证母液是澄清的;
           2. 一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。