BI-765423
目录号 : KM32548 纯度 : 95%

BI-765423 是针对 IL-11 的选择性单克隆抗体抑制剂。BI-765423 可阻断 IL-11 介导的信号传导,抑制成纤维细胞活化,同时可延长哺乳动物健康寿命、对抗人类细胞的衰老转化,减轻炎症衰老相关病理进程。BI-765423 主要用于特发性肺纤维化 (IPF) 等纤维化疾病的研究。

规格 价格 是否有货 数量
1mg
In-stock
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生物活性

BI-765423 is a selective monoclonal antibody inhibitor targeting IL-11. BI-765423 blocks IL-11-mediated signaling, inhibits fibroblast activation, and can extend the healthy lifespan of mammals, counteract cellular senescence in human cells, and alleviate inflammatory aging-related pathological processes. BI-765423 is primarily used in research on fibrotic diseases such as idiopathic pulmonary fibrosis (IPF).

IC50&Target

IL-11

体外研究

BI-765423 can significantly inhibit fibroblast activation and reduce the progression of inflammation and aging related pathological processes in human fibroblast in vitro experiments.

BI-765423 can effectively resist the aging transformation of human cells in vitro and play a potential anti-aging activity.

体内研究

BI-765423 can prolong the healthy lifespan of mammals by inhibiting IL-11 signaling and has inhibitory effects on the pathological processes associated with idiopathic pulmonary fibrosis (IPF).

分子量
146.61 kDa
运输条件

Shipping with dry ice.

储存方式

Store at -80°C for 2 years. Aliquots should be stored at the same temperature after first use to avoid multiple freeze-thaws

种属反应性
Human
同种型
Human IgG1 kappa
Accession号
P20809
应用
ELISA, FACS, Functional assay
性状
Liquid
基因 ID
3589 [NCBI]
复溶方法
The product can be reconstituted/diluted with sterile PBS or saline.
推荐同型对照抗体
Human IgG1 kappa, Isotype Control
暂无相关参考文献
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
动物实验计算换算器
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系客服为您提供正确的澄清溶液配方)
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计算结果:

工作液浓度 mg/ml;

DMSO母液配制方法 mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,

体内配方配制方法μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL ddH2O,混匀澄清。

配置后的溶液总体积

1. 首先保证母液是澄清的;
           2. 一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。