D-Fructose 1-phosphate disodium 是果糖代谢途径中的关键中间代谢物。D-Fructose 1-phosphate disodium 是连接果糖代谢与葡萄糖代谢调控的关健信号分子，其作用方式是作为变构调节剂，抵消葡萄糖激酶- 调节蛋白复合物的抑制作用，从而在底物水平上精细调控肝脏的糖代谢方向。
| 生物活性 |
D-Fructose 1-phosphate disodium is a key intermediate metabolite in the fructose metabolic pathway. As a key signaling molecule linking fructose metabolism and glucose metabolic regulation, D-Fructose 1-phosphate disodium acts as an allosteric modulator to counteract the inhibitory effect of the glucokinase-regulatory protein complex, thereby finely regulating the direction of hepatic glucose metabolism at the substrate level. |
|---|---|
| IC50&Target |
Human Endogenous Metabolite |
| 体外研究 |
D-Fructose 1-phosphate disc can stimulate the activity of glucokinase in isolated liver cells, with a semi maximal effective dose of 30 pmol/mg protein; Pancreatic glucagon can weaken the stimulating effect. D-Fructose 1-phosphate disc (1 mM) is a specific substrate for Clostridium difficile fructose-1-phosphate kinase, with a Km value of 160 μM, and is inhibited by sulfate and phosphate ions. D-Fructose 1-phosphate disc can directly dissociate the large liver GKRP-GK complex, relieving GKRP mediated GCK inhibition. D-Fructose 1-phosphate disodium can inhibit PKM2 in intestinal epithelial cells, thereby driving HIF-1 α activation, hypoxic cell survival, elongation, and enhanced nutrient absorption. |
| 分子式 |
C6H11Na2O9P
|
| 分子量 |
304.10
|
| CAS号 |
71662-09-4
|
| 中文名称 |
D-果糖-1-磷酸二钠盐
|
| 运输条件 |
Room temperature in continental US; may vary elsewhere.
|
| 储存方式 |
-20°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) |
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