Poloxamer 188 is a nonionic linear copolymer with surfactant properties. Poloxamer 188 exhibits anti-thrombotic, anti-inflammatory, and cytoprotective activities in various tissue injury models. Poloxamer 188 can be used for drug delivery.
体外研究
Poloxamer 188 (10-1000 μ M, 5 h) has a protective effect on small brain microvascular endothelial cells (MBEC).
Docetaxel loaded PLGA/poloxam188 nanoparticle led to drug uptake and cytotoxicity of Docetaxel resistant MCF-7 TAX30 breast cancer cells increased compared with Docetaxel loaded PLGA nanoparticle.
Cell Viability Assay
Cell Line:
MBEC
Concentration:
10, 100, 1000 μM
Incubation Time:
5 hours
Result:
Increased the cell number of hypoxic cells at high concentrations
体内研究
Poloxamer 188 (150 mg/kg, intravenous injection, with an interval of 240 minutes between injections) can significantly reduce muscle swelling and lipid peroxidation related to ischemia-reperfusion injury.
Animal Model:
TourniquetInduced Ischemia-Reperfusion Injury in Rats
Dosage:
150 mg/kg
Administration:
i.v
Result:
Reduced the elevated TBARS but not to control levels and SOD activity was at control levels.
分子量
8800(Average)
CAS号
9003-11-6
运输条件
Room temperature in continental US; may vary elsewhere.