| 生物活性 |
RIPK1-IN-35 is a selective and orally active RIPK1 inhibitor with an IC50 of 5.33 nM. RIPK1-IN-35 has a potent protective effect against necroptosis in both human and murine cells. RIPK1-IN-35 shows good therapeutic effects in both TNF-α-induced systemic inflammatory response syndrome and DSS -induced inflammatory bowel disease models. RIPK1-IN-35 can be used to the study of inflammatory diseases related to necroptosis.
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| 分子式 |
C26H18D3F3N6O5
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| 分子量 |
557.5
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| CAS号 |
3103886-96-7
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
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