L-778123 hydrochloride is an inhibitor of FPTase and GGPTase-I with IC50 of 2 nM and 98 nM in enzyme inhibition determination.
IC50 value: 2 nM [1]
Target: FPTase
in vitro: L-778123 can completely inhibit Ki-Ras prenylation. [1] L-778123 as a farnesyltransferase inhibitor can have a good cytotoxic activity as a classic anti-cancer agent. [2]
in vivo: In the dog model, L-778123 inhibits HDJ2 prenylation and produces measurable, albeit slight (5%), levels of unprenylated
Rap1A in PBMCs. [1]
分子式
C22H20N5OCl.HCl
分子量
442.34
CAS号
253863-00-2
运输条件
Room temperature in continental US; may vary elsewhere.